FIG. 6.

Effects of immunomodulation on dystrophin expression after secondary AdV-mediated gene transfer to adult mdx mice. The total number of dystrophin-expressing myofibers on an entire cross-section of the anterior tibialis muscle was determined 10 days after AdV-Dys readministration. Values are expressed as means ± standard errors (n = 3 to 4 animals/group). As was the case after primary AdV-Dys administration, the combination of FK506 plus CTLA4Ig achieved the highest transduction efficiency following secondary AdV-mediated dystrophin gene transfer to adult mdx mouse muscles.