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. 2024 Jan 16;38(4):741–750. doi: 10.1038/s41375-024-02136-7

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A HSPCs from C1498-engrafted AML mice (day 21) were subjected to gene expression analysis (n = 3). B UMAP of single-cell RNA-sequenced (scRNA-Seq) HSPCs from PBS and AML mice. C Gene set enrichment analysis (GSEA) analysis of pathways enriched in HSPCs in AML. D Heatmap of top 20 differentially expressed genes by HSPCs in AML and control. E Gene expression of selected inflammation-related transcripts in AML. F UMAP of HSPC clusters defined into HSC and progenitor subpopulations (MPP-2, MPP-3, MPP-4). G GSEA analysis of pathways enriched in HSPC subpopulation in AML. H Gene expression of selected inflammation associated genes expressed in HSPC subpopulations in AML. Values expressed as mean ± s.d., Statistical significance calculated using ANOVA. *p < 0.05; **P < 0.01; ***P < 0.001.