Table 1.

Functional drug screening identified 39 candidate drug hits that interfered with the CAF2-inhibition of MCF7 ER-α activity at least one concentration included, without boosting MCF7 cell number or showing toxicity to the CAF2 cells.

	Drug name	Mechanism	Class
1	Chloroquine	Anti-malaria agent; chemo/radio-sensitizer	Chemotherapy
2	Daunorubicine	Topoisomerase II inhibitor
3	Etoposide	Topoisomerase II inhibitor
4	Teniposide	Topoisomerase II inhibitor
5	Aldoxorubicin	Topoisomerase II inhibitor
6	BMS863233	Cdc7 inhibitor	Kinase inhibitor
7	Abemaciclib	CDK4/6 inhibitor
8	Palbociclib	CDK4/6 inhibitor
9	PF-670462	CK1delta/CK1epsilon inhibitor
10	DEL-22379	ERK dimerization inhibitor
11	Ulixertinib	ERK inhibitor
12	AMG-925	FLT3/CDK4 inhibitor
13	Pacritinib	JAK2/FLT3 inhibitor
14	Ruxolitinib	JAK1/2 inhibitor
15	Peficitinib	JAK3 inhibitor
16	UNC2881	MER inhibitor
17	Foretinib	MET/VEGFR2 inhibitor
18	Altiratinib	MET/Tie2 inhibitor
19	LY-2584702	P70S6K inhibitor
20	PF-00477736	P70S6K inhibitor
21	LY3009120	pan-RAF inhibitor
22	GDC-0084	PI3K/mTOR inhibitor
23	Enzastaurin	PKCbeta inhibitor
24	Ripasudil	ROCK inhibitor
25	Hydroxyfasudil	ROCK/PKA/PKG/PRK inhibitor
26	GSK269962	ROCK1/2 inhibitor
27	TEW-7197	TGF-β type I receptor ALK4/5 inhibitor
28	OTS-964	TOPK inhibitor
29	Brivanib	VEGFR inhibitor
30	UNC0642	G9a/GLP inhibitor	Differentiating and/or epigenetic modifier
31	Valproic acid	HDAC inhibitor
32	Vidofludimus	DHODH inhibitor
33	Celecoxib	COX-2 inhibitor	NSAID
34	Glasdegib	Smo inhibitor	Hedgehog inhibitor
35	Digoxin	Cardiac glycoside	Other
36	MK-0752	Gamma-secretase/Notch1 inhibitor
37	E7820	Integrin-α2 expression inhibitor
38	NVP-LGK974	PORCN inhibitor
39	Varespladib	Secretory phospholipase A2 inhibitor