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. 2024 Apr 5;14:8053. doi: 10.1038/s41598-024-58400-4

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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ST2825 treatment inhibited cell apoptosis in the anterior basal temporal lobe at 24 h post-SAH. (a–j) Representative photomicrographs of TUNEL staining in the inferior basal temporal lobe (a–e, × 100, f–j, × 400). (k) Statistical data revealed that ST2825 treatment significantly reduced the TUNEL-positive cells compared with SAH and DMSO treated groups. (l) MyD88 inhibition reduced the levels of cleaved caspase-3 in the anterior basal temporal lobe at 24 h post SAH. The upper panel shows representative protein levels of cleaved caspase-3. Tubulin was detected as a loading control. The bottom panel shows quantitative data of cleaved caspase-3. Data are expressed as mean ± SD (n = 6 in each group). ***p < 0.001 compared with the sham group, ^##p < 0.01 compared with the SAH group, ^###p < 0.001 compared with the SAH group, NS, no statistic difference compared with the SAH group.