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. 2024 Apr 5;7:415. doi: 10.1038/s42003-024-06120-w

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Heatmap of all TET3 catalytic target genes (n = 104) associated with hyper-DMRs. b GO analysis of hyper-DMR containing TET3 catalytic target genes revealing enrichment for neural terms. Line represents significance (p < 0.05). c IGV tracks of DNA methylation levels at Neurog2 and Sox1 loci (both downregulated in Tet3^m/m and Tet3^–/–). Hyper-DMRs are highlighted in orange. d Heatmap of all TET3 non-catalytic target genes (n = 239) associated with hypo-DMRs. e GO analysis of hypo-DMR-containing TET3 non-catalytic target genes revealing enrichment for mesodermal signaling pathways. Line represents significance (p < 0.05). f IGV tracks of DNA methylation levels at Wnt10a and Myl9 loci (both upregulated in Tet3^–/– but not in Tet3^m/m NEs). Hypo-DMRs are highlighted in orange.