Table 2.
Uni- and multi-variable logistic regression analyses to identify factors associated with PHLF based on preoperative data.
| Variable | Univariable regression | Multivariable regressiona | ||
|---|---|---|---|---|
| OR (95% CI) | P | OR (95% CI) | P | |
| Age (years) | 1.012 (0.981–1.044) | 0.459 | ||
| Male | 0.316 (0.072–1.388) | 0.127 | - | - |
| Positive HBsAg | 0.548 (0.200–1.500) | 0.242 | - | - |
| Positive anti-HCV | 2.667 (0.469–15.157) | 0.269 | - | - |
| Platelet count (109/L) | 0.988 (0.982–0.995) | < 0.001 | ||
| Albumin (g/L) | 0.891 (0.837–0.948) | < 0.001 | ||
| Total bilirubin (μmol/L) | 1.092 (1.034–1.153) | 0.002 | ||
| AST (U/L) | 1.011 (1.003–1.019) | 0.005 | ||
| Creatinine (μmol/L) | 1.000 (0.990–1.011) | 0.979 | - | - |
| Prothrombin time (sec) | 1.762 (1.315–2.360) | < 0.001 | 1.477 (1.069–2.042) | 0.018 |
| CSPH | 5.221 (2.375–11.479) | < 0.001 | 1.979 (0.698–5.615) | 0.199 |
| ALBI score | 4.728 (2.271–9.845) | < 0.001 | 2.457 (1.012–5.970) | 0.047 |
| FIB-4 index | 1.304 (1.151–1.478) | < 0.001 | 1.215 (1.043–1.415) | 0.012 |
| Tumor size (cm) | 1.061 (0.975–1.154) | 0.172 | - | - |
| Tumor number | 0.888 (0.342–2.309) | 0.808 | - | - |
| Major resection | 2.364 (1.087–5.140) | 0.030 | 2.433 (1.007–5.879) | 0.048 |
ALBI albumin-bilirubin, AST aspartate aminotransferase, CSPH clinically significant portal hypertension, FIB-4 fibrosis-4, HBsAg Hepatitis B surface antigen, HCV Hepatitis C virus, MELD model for end-stage liver disease, PHLF post-hepatectomy liver failure.
aTo avoid collinearity, platelet count, albumin, total bilirubin, and AST were not enrolled into the multivariable regression model.