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. 2024 Apr 5;14:8070. doi: 10.1038/s41598-024-58181-w

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Inflammatory markers associated with macrophage polarization and infiltration in granulosa cells do not reflect differences in leptin signalling in mice lacking long isoform of leptin receptor (db) or leptin (ob). Box-whisker plots illustrating the gene expression of chemokines and cytokines secreted from granulosa cells (GCs) associated with macrophage commitment to M1 (A) and M2 (B), as well as macrophage infiltration (C) in the ovary of mice lacking long isoform of leptin (db/db) and mice lacking leptin (ob/ob) mice after RNA sequencing (RNA-seq) analysis. (A) Chemokine (C-X3-C motif) ligand 1 (Cx3cl1), chemokine (C-X-C motif) ligand 1 (Cxcl1), Cxcl16, Cxcl5, interleukin 18 (Il-18), Il-23a. (B) Chemokine (C–C motif) ligand 17 (Ccl17), Il4, Transforming growth factor, beta 1 (Tgfb1). (C) Ccl25, colony stimulating factor 1 (Csf1), Cxcl12, intercellular adhesion molecule 1 (Icam1), inhibin beta-B (Inhbb), macrophage migration inhibitory factor (Mif), Retinoic acid receptor responder protein 2 (Rarres2). CT—control for mutants (CT db or CT ob); MUT mutant mice (db/db or ob/ob). Expression level presented as arbitrary units (AU).