FIG. 1.

Evaluation of chimpanzees C-166 (▪) and C-384 (•) after cervical and intravenous inoculation, respectively, of HIV-1_JC499. (a) Plasma HIV-1 RNA levels. (b) Percentages of CD4⁺ T cells in peripheral blood. (c) CD4/CD8 ratios in peripheral blood. (d) Percentages of CD4⁺ and CD8⁺ T cells in peripheral lymph nodes. For C-166 and C-384, the LN biopsies were done 12 (✖), 24 (□), and 49 (⧫) weeks after inoculation. All of the control LN biopsies were performed on chimpanzees infected with different HIV-1 strains for various times.