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. 1998 Jun;72(6):4623–4632. doi: 10.1128/jvi.72.6.4623-4632.1998

FIG. 5.

FIG. 5

Immune hyperactivation and lymphocyte apoptosis in LN from progressor chimpanzees. (a) Follicular hyperplasia in a hematoxylin-eosin-stained LN section from C-384. Magnification, ×40. (b) Histology of normal LN tissue from nonprogressor C-534. Magnification, ×40. (c) TUNEL-positive lymphocytes in germinal center of LN from C-166. Magnification, ×100. (d) TUNEL-positive lymphocytes in paracortex of LN from C-384. Magnification, ×1,000. (e) Tingible body macrophage containing multiple phagocytosed apoptotic nuclei in germinal center of LN from C-166. Magnification, ×1,000. (f) TUNEL-stained LN tissue from nonprogressor C-304. Magnification, ×400. (g and h) Transmission electron micrograph of LN biopsy tissue from C-384, showing apoptotic lymphocytes with highly condensed chromatin, cytoplasmic condensation, and plasmalemmal zeiosis. Magnification, ×27,000.