Figure 2. Neutrophils coordinate DEFA1A3-mediated urinary tract infection burden protection against uropathogenic E. coli in vivo.

(A, B) At 6 hpi of CFT073 superinfection challenge, (A) bladder and (B) individual kidney lysates from anti-Gr1– and isotype-treated DEFA^0/0 and DEFA^4/4 littermate mice were quantified for bacterial burdens and are represented as the mean CFU/ml ± SD of the respective organ from six biological replicates. One-way ANOVA with Tukey’s post hoc test was applied to evaluate differences between groups.