TABLE 5.

Recommendations for future research on ASD in RASopathies.

Molecular confirmation of RASopathy diagnosis Sufficiently sized samples for the effect being studied Systematic in‐depth assessment of all participants, regardless of screening status Use of a broad arsenal of validated instruments to comprehensively cover the different behavioral aspects of ASD Dimensional approach of ASD symptoms Contrasting of research findings with clinical assessment of participants Systematic measurement and reporting of possible modifiers (e.g., age, sex, cognition, ADHD symptoms) Prospective or repetitive cross‐sectional designs to assess age effects Matching the study sample and comparison group to the main research question