Table 2.

Diseases associated with crotonylation metabolite.

Diseases	Metabolite	Regulatory mechanism	References
Hepatocellular carcinoma	HDACs	By adding HDACs inhibitor, it founded that lysine crotonylation can affect the Hepatocellular carcinoma (HCC)cell migration, and decrease the proliferation ability of hepatoma cell.	[48]
Wilms tumor	YEATS domain of MLLT1	Mutations in the YEATS domain of MLLT1 have been shown to be functionally relevant in Wilms tumor.	[122]
Hepatocellular carcinoma	ACOX2	ACOX2 is a regulator of Kcr.Compared with normal mice, experiments on ACOX2 mice have uncovered that the level of non-histone Kcr was dowenregulated while the level of histone (H2b) K86cr was upregulated.	[54]
Ovarian cancer	HDACs	HDAC inhibitor suberoylanilide hydroxamic acid (SAHA) could inhibit growth of cancer cells, inducing expression of tumor suppressor genes, apoptosis, G2/M arrest, and autophagy.	[123]
inflammation	AF9 YEATS domain	AF9 YEATS domain has selectively higher binding affinity on crotonyllysine than acetyllysine, and AF9 YEATS Links the inflammatory genes' response to histone crotonylation.	[45]