Table 4.
Comparability of effect of intervention on HHC identified and starting TPT in main study and in follow-up study.
| HHC identified per 100 TB |
Estimates of differences in rates (95% CI) |
|
|---|---|---|
| Original control sites |
Original intervention sites |
|
| All phases with vs without intervention | Phase 4 vs 1,2,3 | Phase 2,3,4 vs 1 |
| All sites in all countries (n = 16). Difference in ratesa | 212 (104, 320) | 144 (−34, 322) |
| Difference of differences (Streamlined vs Original) | 68 (−140, 276) | |
| Sites in LMIC countries (n = 12). Difference in ratesa | 229 (130, 328) | 203 (4, 400) |
| Difference of differences (Streamlined vs Original) | 26 (−196, 248) | |
| HHC starting TPT per 100 TB | Original control sites |
Original intervention sites |
|
All phases with vs without intervention |
Phase 4 vs 1,2,3 |
Phase 2,3,4 vs 1 |
| All sites in countries (n = 16). Difference in ratesb | 33 (−77, 144) | 35 (−16, 86) |
| Difference of differences (Streamlined vs Original) | −2 (−124, 121) | |
| Sites in LMIC countries (n = 12). Difference in ratesb | 26 (−27, 80) | 47 (−24, 119) |
| Difference of differences (Streamlined vs Original) | −21 (−110, 68) | |
Rates and 95% CI per 100 TB index TB patients. Differences that are significant are in bold.
a
Estimated with marginal model with log link using NLESTIMATE, corrected for clustering.
b
Estimated with marginal model with log link using NLESTIMATE, corrected for clustering, and small clusters.