Table 3.
Cognitive profile and MRI CAA-burden score in patients and controls
| n | sCAA, all 82 |
sCAA ICH+ 23 |
sCAA ICH- 59 |
D-CAA, all 56 |
D-CAA symptomatic 25 |
D-CAA presymptomatic 37 |
Controls 43 |
|---|---|---|---|---|---|---|---|
| Executive Function, Z-score* mean(SD) | -0.1 (1.2) | -0.3 (1.6) | -0.1 (1.1) | 0.3 (1.2) | 0.1 (1.3) | 0.6 (1.0) | 0.6 (0.7) |
| Processing speed, Z-score* mean(SD) | -0.8 (1.3) | -1.0 (1.5) | -0.7 (1.2) | -0.3 (1.2) | -0.6 (1.4) | -0.1 (0.9) | 0.2 (0.7) |
| Memory, Z-score* mean(SD) | -0.7 (1.0) | -1.0 (1.1) | -0.6 (1.0) | -0.7 (0.9) | -1.1 (0.9) | -0.4 (0.8) | 0.4 (0.8) |
| CAA-burden score, median[IQR] | 4 [4,5] | 4 [3,6] | 4 [4,5] | 4 [1,5] | 4 [4,5] | 1 [1,4] | 1 [1,1] |
| Frontal lobe cSS, n(%) | 47 (57) | 12 (52) | 35 (59) | 14 (29) | 10 (40) | 4 (16) | 0 (0) |
| Frontal lobe CMB, n(%) | |||||||
| 0 | 11 (13) | 3 (16) | 8 (16) | 20 (25) | 1 (4) | 19 (76) | 39 (91) |
| 1–10 | 35 (43) | 10 (53) | 25 (51) | 1 (2) | 1 (4) | 0 (0) | 2 (5) |
| 11–20 | 4 (5) | 1 (5) | 3 (6) | 6 (11) | 5 (20) | 1 (4) | 0 (0) |
| >20 | 18 (22) | 5 (26) | 13 (27) | 21 (38) | 16 (64) | 5 (20) | 0 (0) |
cSS cortical superficial siderosis; CMB cerebral microbleeds; D-CAA Dutch-type cerebral amyloid angiopathy; sCAA sporadic CAA
* age, sex and education adjusted Z-scores