Table 4.
RVP scores
| Test product | Reference product | LSMean (95% CI) | Difference in LSMeans (95% CI) Test—Reference | Tukey adjusted P-value | Cohen’s d effect size | |
|---|---|---|---|---|---|---|
| Test product | Reference product | |||||
| EPEN-0 mg (n = 38) | No Product (n = 37) |
0.00487 (− 0.00276, 0.01249) |
0.00255 (− 0.00516, 0.01025) |
0.00232 (− 0.01127, 0.01591) |
0.9897 | 0.11 |
| EPEN-12 mg (n = 39) | No Product (n = 37) |
0.01950 (0.01199, 0.02702) |
0.00255 (− 0.00516, 0.01025) |
0.01696 (0.00345, 0.03046) |
0.0061* | 0.80 |
| EPEN-18 mg (n = 39) | No Product (n = 37) |
0.01752 (0.01000, 0.02504) |
0.00255 (− 0.00516, 0.01025) |
0.01497 (0.00146, 0.02848) |
0.0218* | 0.71 |
| Combustible Cigarette (n = 39) | No Product (n = 37) |
0.02068 (0.01317, 0.02820) |
0.00255 (− 0.00516, 0.01025) |
0.01814 (0.00464, 0.03164) |
0.0027* | 0.85 |
| EPEN-12 mg (n = 39) | EPEN-0 mg (n = 38) |
0.01950 (0.01199, 0.02702) |
0.00487 (− 0.00276, 0.01249) |
0.01464 (0.00120, 0.02807) |
0.0253* | 0.69 |
| EPEN-18 mg (n = 39) | EPEN-0 mg (n = 38) |
0.01752 (0.01000, 0.02504) |
0.00487 (− 0.00276, 0.01249) |
0.01265 (− 0.00084, 0.02614) |
0.0776 | 0.60 |
| Combustible Cigarette (n = 39) | EPEN-0 mg (n = 38) |
0.02068 (0.01317, 0.02820) |
0.00487 (− 0.00276, 0.01249) |
0.01581 (0.00235, 0.02928) |
0.0125* | 0.74 |
| EPEN-18 mg (n = 39) | EPEN-12 mg (n = 39) |
0.01752 (0.01000, 0.02504) |
0.01950 (0.01199, 0.02702) |
− 0.00199 (− 0.01532, 0.01134) |
0.9939 | 0.09 |
| Combustible Cigarette (n = 39) | EPEN-12 mg (n = 39) |
0.02068 (0.01317, 0.02820) |
0.01950 (0.01199, 0.02702) |
0.00118 (− 0.01215, 0.01451) |
0.9992 | 0.06 |
| Combustible Cigarette (n = 39) | EPEN-18 mg (n = 39) |
0.02068 (0.01317, 0.02820) |
0.01752 (0.01000, 0.02504) |
0.00317 (− 0.01012, 0.01646) |
0.9648 | 0.15 |
Results obtained using an ANOVA on post-product use results with fixed effects of product, period, sequence and a random effect of subject nested within sequence (*indicates p = < 0.05). Participants with assessments flagged to indicate non-compliance, who also meet the performance outlier threshold (± 1.5 × IQR), have been excluded from the analysis of this data
ANOVA, analysis of variance; IQR, interquartile range
Baseline defined as − 85 to − 45 min pre-product use