Table 5.
SEQ Scores
| Test product | Reference product | LSMean (95% CI) | Difference in LSMeans (95% CI) Test—Reference | Tukey Adjusted P-value |
Cohen’s d effect size | ||
|---|---|---|---|---|---|---|---|
| Test product | Reference product | ||||||
| Positive Emotion Score | EPEN-0 mg (n = 38) | No Product (n = 37) |
5.4 (0.7, 10.2) |
− 0.9 (− 5.8, 4.0) |
6.4 (− 1.5, 14.2) |
0.1743 | 0.52 |
| EPEN-12 mg (n = 39) | No Product (n = 37) |
8.0 (3.3, 12.8) |
− 0.9 (− 5.8, 4.0) |
8.9 (1.0, 16.9) |
0.0190* | 0.73 | |
| EPEN-18 mg (n = 39) | No Product (n = 37) |
11.1 (6.4, 15.8) |
− 0.9 (− 5.8, 4.0) |
12.0 (4.1, 19.9) |
0.0004* | 0.98 | |
| Combustible Cigarette (n = 39) | No Product (n = 37) |
12.0 (7.2, 16.7) |
− 0.9 (− 5.8, 4.0) |
12.9 (4.9, 20.8) |
0.0001* | 1.05 | |
| EPEN-12 mg (n = 39) | EPEN-0 mg (n = 38) |
8.0 (3.3, 12.8) |
5.4 (0.7, 10.2) |
2.6 (− 5.2, 10.4) |
0.8919 | 0.21 | |
| EPEN-18 mg (n = 39) | EPEN-0 mg (n = 38) |
11.1 (6.4, 15.8) |
5.4 (0.7, 10.2) |
5.7 (− 2.1, 13.5) |
0.2693 | 0.46 | |
| Combustible Cigarette (n = 39) | EPEN-0 mg (n = 38) |
12.0 (7.2, 16.7) |
5.4 (0.7, 10.2) |
6.5 (− 1.3, 14.3) |
0.1506 | 0.53 | |
| EPEN-18 mg (n = 39) | EPEN-12 mg (n = 39) |
11.1 (6.4, 15.8) |
8.0 (3.3, 12.8) |
3.1 (− 4.6, 10.8) |
0.8029 | 0.25 | |
| Combustible Cigarette (n = 39) | EPEN-12 mg (n = 39) |
12.0 (7.2, 16.7) |
8.0 (3.3, 12.8) |
3.9 (− 3.8, 11.7) |
0.6222 | 0.32 | |
| Combustible Cigarette (n = 39) | EPEN-18 mg (n = 39) |
12.0 (7.2, 16.7) |
11.1 (6.4, 15.8) |
0.8 (− 6.8, 8.5) |
0.9981 | 0.07 | |
| Negative Emotion Score | EPEN-0 mg (n = 38) | No Product (n = 37) |
− 6.3 (− 11.0, − 1.7) |
− 1.4 (− 6.2, 3.4) |
− 5.0 (− 12.7, 2.8) |
0.3997 | 0.41 |
| EPEN-12 mg (n = 39) | No Product (n = 37) |
− 10.0 (− 14.7, − 5.4) |
− 1.4 (− 6.2, 3.4) |
− 8.7 (− 16.5, − 0.8) |
0.0220* | 0.71 | |
| EPEN-18 mg (n = 39) | No Product (n = 37) |
− 11.8 (− 16.4, − 7.2) |
− 1.4 (− 6.2, 3.4) |
− 10.4 (− 18.2, − 2.6) |
0.0028* | 0.86 | |
| Combustible Cigarette (n = 39) | No Product (n = 37) |
− 13.1 (− 17.8, − 8.5) |
− 1.4 (− 6.2, 3.4) |
− 11.8 (− 19.6, − 3.9) |
0.0005* | 0.97 | |
| EPEN-12 mg (n = 39) | EPEN-0 mg (n = 38) |
− 10.0 (− 14.7, − 5.4) |
− 6.3 (− 11.0, − 1.7) |
− 3.7 (− 11.4, 4.0) |
0.6714 | 0.31 | |
| EPEN-18 mg (n = 39) | EPEN-0 mg (n = 38) |
− 11.8 (− 16.4, − 7.2) |
− 6.3 (− 11.0, − 1.7) |
− 5.5 (− 13.1, 2.2) |
0.2891 | 0.45 | |
| Combustible Cigarette (n = 39) | EPEN-0 mg (n = 38) |
− 13.1 (− 17.8, − 8.5) |
− 6.3 (− 11.0, − 1.7) |
− 6.8 (− 14.5, 0.9) |
0.1109 | 0.56 | |
| EPEN-18 mg (n = 39) | EPEN-12 mg (n = 39) |
− 11.8 (− 16.4, − 7.2) |
− 10.0 (− 14.7, − 5.4) |
− 1.8 (− 9.4, 5.9) |
0.9687 | 0.15 | |
| Combustible Cigarette (n = 39) | EPEN-12 mg (n = 39) |
− 13.1 (− 17.8, − 8.5) |
− 10.0 (− 14.7, − 5.4) |
− 3.1 (− 10.7, 4.5) |
0.7936 | 0.26 | |
| Combustible Cigarette (n = 39) | EPEN-18 mg (n = 39) |
− 13.1 (− 17.8, − 8.5) |
− 11.8 (− 16.4, − 7.2) |
− 1.3 (− 8.9, 6.3) |
0.9884 | 0.11 | |
Results obtained using an ANCOVA with fixed effects of product, period, sequence and a random effect of subject nested within sequence with the baseline value as a covariate (*indicates p = < 0.05). Baseline defined as Pre-IP Use.