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. 1998 Jun;72(6):4657–4666. doi: 10.1128/jvi.72.6.4657-4666.1998

FIG. 1.

FIG. 1

Wild-type EBNA-1 and its derivatives. The DNA linking domains (grey boxes) (18, 36), the DNA binding and dimerization domain (hatched box) (3, 6, 28, 38, 49), the internal repeated sequence consisting entirely of glycine and alanine residues (Gly-Gly-Ala), and the nuclear localization sequence (NLS) (2) of EBNA-1 are noted. Regions rich in basic (+) and acidic (−) residues are indicated. The protein products of vectors encoding wild-type EBNA-1 and its derivatives are shown. EBNA-1 contains amino acids (aa) 1 to 641 and is wild-type EBNA-1 of the B95-8 strain of EBV (5). NΔ330-641 contains aa 331 to 641 of EBNA-1 (29), and NΔ450-641 contains the nuclear localization sequence (aa 379 to 386) fused in frame to aa 451 to 641 of EBNA-1 (40).