(A) Area under the receiver-operating characteristics curves for continuous AFP, AFP-L3, and DCP relationship with recurrence (n = 285). (B) Relationship between AFP-L3 and DCP values stratified by HCC recurrence. Low (AFP-L3 ≥15% and DCP ≥7.5 ng/ml) cut-off represented by short-dashed line. High (AFP-L3 ≥25% and DCP ≥15 ng/ml) dual biomarker positive model represented by the dash-dot line. AFP, alpha-fetoprotein; AFP-L3, AFP bound to Lens culinaris agglutinin; DCP, des-gamma-carboxyprothrombin.