Table 2.
Explant characteristics on pathology by dual positivity for AFP-L3 ≥15% and DCP ≥7.5 ng/ml.
| Overall (N = 285) | Negative for dual biomarker elevation (n = 265) | AFP-L3 ≥15% and DCP ≥7.5 ng/ml (n = 20) | p value | |
|---|---|---|---|---|
| Median largest viable tumor on explant (cm, IQR) | 1.0 (0–1.8) | 0.8 (0–1.7) | 2.0 (1.6–2.9) | <0.001¶ |
| Median total viable tumor diameter on explant (cm, IQR) | 1.2 (0–3.0) | 1.0 (0–2.7) | 4.9 (3.1–8.2) | <0.001¶ |
| Median number of viable HCC lesions on explant (n, IQR) | 1.0 (0–2) | 1.0 (0–2) | 4.0 (2.5–5) | <0.001¶ |
| Vascular invasion (n, %) | 13 (4.6) | 5 (1.9) | 8 (40.0) | <0.001* |
| High risk pathology on explant (n, %) | 47 (16.5) | 30 (11.3) | 17 (85.0) | <0.001* |
| Explant outside Milan (n, %) | 40 (14.0) | 28 (10.6) | 12 (60.0) | <0.001* |
| RETREAT score (score, IQR) | 1 (0–2) | 1 (0–2) | 3 (2–4) | <0.001¶ |
| Recurrence-free survival (HR, 95% CI) | – | Reference | 26.6 (10.3–68.9) | <0.001Δ |
| Overall survival (HR, 95% CI) | – | Reference | 8.2 (3.4–19.6) | <0.001Δ |
AFP-L3, AFP bound to Lens culinaris agglutinin; DCP, des-gamma-carboxyprothrombin; HCC, hepatocellular carcinoma; HR, hazard ratio; RETREAT, risk estimation of tumor recurrence after transplant.
*
Chi squared test.
¶
Two-sample exact Wilcoxon rank-sum (Mann-Whitney) test.
Δ
Cox proportional hazards test.