Table 3.
In vitro antibacterial effect of ebselen on Gram-negative bacteria.
| Microorganism | Strain | MIC (μg/mL) | Reference |
|---|---|---|---|
| E. coli | Clinical isolate (ESBL) | 64–>128 | [46] |
| Clinical isolates (MβLs) | |||
| K. pneumonia | Clinical isolate (ESBL) | >128 | |
| Clinical isolate (NDM-1) | |||
| P. aeruginosa | Clinical isolate | >128 | |
|
| |||
| Y. pseudotuberculosis | Yp III | 2∗/∗∗ (plus 0.5 μM Ag+) | [63] |
|
| |||
| H. pylori | NCTC11637 | 3.13 | [15] |
| Clinical isolate | |||
|
| |||
| A. baumanii | ATCC 17978 | 32∗ | [66] |
| E. coli | MG1655 | 128∗ | |
|
| |||
| Enterobacteriaceae | Reference strains | 12.5–50 | [43] |
|
| |||
| E. coli | ATCC 25922 | 274 | [32] |
|
| |||
| S. marcescens | MTCC 2465 | 14∗∗∗ | [67] |
|
| |||
| A. baumanii | ATCC BAA1605 | 16 | [52] |
| E. coli O157:H7 | ATCC 700728 | 32 | |
| K. pneumonia | ATCC BAA2146 | 64 | |
| P. aeruginosa | ATCC 9721 | >256 | |
| S. Typhimurium | ATCC 700720 | 32 | |
∗ μM; ∗∗MIC90; ∗∗∗MIC50; ATCC: American Type Culture Collection; ESBL: extended-spectrum beta-lactamases; MβLs: metallo-beta-lactamases; MTCC: Microbial Type Culture Collection; NDM-1: New Delhi metallo-beta-lactamases.