Table 3.
Predictors of arrhythmic events in Brugada syndrome patients with implantable loop recorder
| Univariate analysis | Multivariate analysis | |||||||
|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | |||
| Lower | Upper | Lower | Upper | |||||
| All arrhythmic events | ||||||||
| Female sex | 1.5 | 0.8 | 1.8 | .51 | ||||
| Age > 50 years | 1.8 | 1.2 | 2.8 | .002 | 1.7 | 1.1 | 2.5 | .016 |
| ILR for symptoms | 3.1 | 1.6 | 5.9 | .001 | 2.5 | 1.3 | 4.9 | .001 |
| ILR for syncope | 1.2 | 0.8 | 1.8 | .46 | ||||
| ILR for palpitations | 1.9 | 1.2 | 2.9 | .003 | 1.4 | 0.9 | 2.3 | .10 |
| Proband status | 1.6 | 0.9 | 2.7 | .069 | ||||
| Family history of BrS | 1.1 | 0.7 | 1.6 | .82 | ||||
| Family history of SCD | 1.2 | 0.8 | 1.9 | .37 | ||||
| Shanghai score | 1.0 | 0.9 | 1.2 | .65 | ||||
| Type 1 ECG | 1.0 | 0.7 | 1.5 | .92 | ||||
| SCN5A P/LP variant | 1.0 | 0.6 | 1.8 | .94 | ||||
| Positive EP study | 1.9 | 0.9 | 3.9 | .085 | ||||
| Ventricular arrhythmic events | ||||||||
| Female sex | 0.8 | 0.3 | 2.1 | .69 | ||||
| Age | 0.1 | 0.9 | 1.0 | .98 | ||||
| ILR for syncope | 1.3 | 0.5 | 3.3 | .51 | ||||
| ILR for symptoms | 32.1 | 0.5 | 2267.4 | .11 | ||||
| Proband status | 3.8 | 0.9 | 16.4 | .073 | ||||
| Family history of BrS | 1.0 | 0.4 | 2.7 | .95 | ||||
| Family history of SCD | 0.9 | 0.3 | 2.4 | .81 | ||||
| Shanghai score | 1.3 | 0.9 | 1.7 | .124 | ||||
| Type 1 ECG | 0.8 | 0.3 | 1.9 | .60 | ||||
| BrS pathogenic variant | 1.7 | 0.6 | 4.7 | .33 | ||||
| Positive EP study | 9.0 | 3.4 | 24.2 | <.001 | ||||
Univariate and multivariate COX regression analysis for predictors of arrhythmias.
Abbreviations: BrS, Brugada syndrome; CI, confidence interval; EP, electrophysiological; HR, hazard ratio; ICD, implantable cardioverter defibrillator; ILR, implantable loop recorder; OR, odds ratio; PM, pacemaker; SCD, sudden cardiac death.