Table 2.
Characteristics of studies included in the meta-analysis
| ID | Study | Country | Database | Period | Quality score | Sample size (Fatty liver/Normal liver) | Diagnostic method for fatty liver | Age (years) | Male (%) | Overweight (%) | Tumor location (%) | Disease stage (n) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Besutti et al. [14] | Italy | local population-based Cancer Registry and from the electronic medical records of all the Local Health Authority hospitals of the province | 2010 to 2016 | 5 | 202 (60/142) | L/S ratio | 68±14 | 59 | NA | NA | Stage II (77) |
| Stage III (125) | ||||||||||||
| 2 | Murono et al. [15]a | Japan | University of Tokyo Hospital | 2004 to 2011 | 7 | 603 (63/540) | L/S ratio | 67±11 | 60.4 | 22.1 | Colon (63.5) | Stage I (160) |
| Rectum (36.5) | Stage II (197) | |||||||||||
| Stage III (172) | ||||||||||||
| 3 | Kondo et al. [16] | Japan | Keio University Hospital | 2000 to 2011 | 7 | 956 (73/876) | NFS | Fibrotic liver 75.3±9.3 | 59.4 | 22.0 | Right colon (35.3) | Stage I (293) |
| Normal liver 64.9±11.7 | Left colon (42.7) | Stage II (327) | ||||||||||
| Rectum (22.0) | Stage III (333) | |||||||||||
| 4 | Xi et al. [17] | China | Renji Hospital, Shanghai Jiaotong University | 1993 to 2002 | 5 | 243 (55/188) | Ultrasound | Fatty liver 64±10.8 | 56.4 | NA | NA | NA |
| Normal liver 63±13.2 | ||||||||||||
| 5 | NCRCC database | China | Sencond Affiliated Hospital of Zhejiang University School of Medicine | 2012 to 2022 | 8 | 414 (97/317) | L/S ratio | 63.5±12.6 | 75.6 | 6.5 | Right colon (29.7) | Stage I (32) |
| Left colon b(70.3) | Stage II (110) | |||||||||||
| Stage III (272) |
a
Study with publication bias form Egger’s test;
b
Rectum was included in the left colon in this study.
L/S ratio: Liver-spleen ratio on CT scans; NFS: NAFLD fibrosis score; NCRCC: National Colorectal Cancer Cohort.