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Safety of S-1, number of subjects (%)
| Neoadjuvant chemotherapy with S-1 (N = 106) | |
|---|---|
| Patients with any AE | 78 (74) |
| AE leading to death | 0 (0) |
| Any SAE | 1 (1) |
| AE leading to discontinuation of S-1 | 20 (19) |
| White blood cell decrease | 30 (28) |
| Anemia | 27 (25) |
| Thrombocytopenia | 26 (25) |
| Bilirubin increase | 19 (18) |
| Pruritus | 8 (8) |
| ALT increase | 9 (8) |
AE, adverse event; SAE, serious adverse event.
