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. 2024 Apr 6;14:37. doi: 10.1186/s13550-024-01101-w

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — [¹⁷⁷Lu]Lu-PP-F11N and SSTR2 imaging in all patients. [¹⁷⁷Lu]Lu-PP-F11N SPECT maximum intensity projection (MIP) of patient 1–8 at 24 h p.i. without (left) and with (middle) Entresto^® premedication. MIP of the corresponding SST2R PET/CT for each patient (right). Green arrows: MTC metastases, visible in [¹⁷⁷Lu]Lu-PP-F11N scintigraphy. Red arrows: MTC metastases only visible in SST2R PET/CT in a single patient (only two of multiple metastases labelled). Blue arrows: urine contamination. Orange arrowheads: physiological stomach uptake. Furthermore, uptake in kidneys, bowels and urinary bladder is visible in all patients