Table 2.
Adverse events
| Patient no | Definition | Grade w/o | Grade w | Patient no | Definition | Grade w/o | Grade w |
|---|---|---|---|---|---|---|---|
| 1 | Hot flashes | 1 | 1 | 6 | Hypocalcemia | 1 | – |
| 1 | Flush | 1 | 1 | 6 | Hypokalemia | 1 | – |
| 1 | Nausea | 1 | 1 | 6 | Headache | 1 | – |
| 1 | Dizziness | 1 | 1 | 6 | Hot flashes | 1 | – |
| 1 | Sweating | 1 | – | 6 | Nausea | 1 | 1 |
| 1 | Hypocalcemia | – | 2 | 6 | Flushing | 1 | 1 |
| 2 | Hypocalcemia | 1 | – | 6 | Hyperhidrosis | – | 1 |
| 2 | Dizziness | 1 | 1 | 7 | Flushing | 1 | 1 |
| 2 | Hyperhidrosis | 1 | 1 | 7 | Nausea | 1 | 1 |
| 3 | Abdominal pain | 1 | – | 7 | Vomiting | 1 | – |
| 3 | Paresthesia | 1 | – | 7 | Hyperhidrosis | – | 1 |
| 3 | Hot flashes | – | 1 | 7 | Hypokalemia | – | 1 |
| 3 | Dizziness | 1 | 1 | 7 | Fatigue | – | 1 |
| 3 | Nausea | 1 | 1 | 8 | Nausea | 1 | 1 |
| 4 | Hot flashes | 1 | 1 | 8 | Headache | 1 | 1 |
| 4 | Neck pain | 1 | 1 | 8 | Dizziness | – | 1 |
| 5 | Paresthesia | – | 1 |
Adverse effects without (w/o) and with (w) Entresto® premedication, graded according to CTCAE version 4.03