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. 2024 Apr 6;15:2987. doi: 10.1038/s41467-024-47213-8

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Prophylactic efficacy of 41-6 against a lethal challenge with the NiV_M strain. Antibodies diluted in PBS were administered at 10 mg/kg through IP 24 h before viral infection. Control group animals received the same volume of PBS. Hamsters were challenged with a virus by IP route (day 0). The weight change was collected daily for 14 days after inoculation and the survival was observed for a duration of 28 days. b Therapeutic efficacy of 41-6 against a lethal challenge with the NiV_M strain. Hamsters were treated with PBS buffer or 10 mg/kg 41-6 for 3 h and 3 days after intraperitoneal inoculation with the NiV virus. The weight change was collected daily for 14 days after inoculation and the survival was observed for a duration of 28 days. Error bars represent the mean ± S.D. Data (n = 6 biologically independent animals per group) were analyzed by the two-sided log-rank (Mantel‒Cox) test using Prism software (*p < 0.1, ***p < 0.001) (see also Supplementary Fig. 4). MST median survival time. The schemes were created with BioRender.com. The PBS-treated animals in b are identical to those in Supplementary Fig. 4b, c. Source data are provided as a Source Data file.