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. 2024 Apr 6;7:418. doi: 10.1038/s42003-024-06046-3

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Plot shows the −log₁₀(P) for associations of genetic variants with Fuchs endothelial corneal dystrophy across 22 autosomal chromosomes plus chromosome X. Genome-wide significant loci are labeled by names of candidate genes; novel loci are highlighted in red with bold gene names. The red line indicates the genome-wide significance threshold (P < 5 × 10⁻⁸). A y-axis break is used to include the most significant variant at TCF4.