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. 2024 Apr 6;7:418. doi: 10.1038/s42003-024-06046-3

Fig. 4. Structure of LM511 and predicted impact of missense variants in laminin genes LAMA5 (α5) and LAMB1 (β1).

Fig. 4

a Structural organization of the laminin-511 (LM511) heterotrimer. The green color denotes the LAMA5 subunit, blue denotes LAMB1, and pink denotes LAMC1. Significant FECD variants are located on the short arms of α5 and β1, in LE (laminin-type epidermal growth factor (EGF) like) domains LE22 and LE6, respectively. The insets depict AlphaFold 2 predictions of these domains, and the locations of the mutated residues are shown in orange. b (Top) Predicted surface structure of the α5 LE22 domain with and without the Gly2156Glu variant. (Bottom) Predicted surface structure of the β1 LE22 domain with and without the Arg795Gly variant.