Table 1.

Associations of the top single nucleotide polymorphism (SNP) at the TCF4 locus, rs11659764, in Million Veteran Program (MVP) cohorts

Ancestry	Odds ratio [95% CI]	P-value	EAF cases	EAF controls
EUR	6.41 [5.86, 7.01]	9.4 × 10−360	0.222	0.045
AFR	7.57 [4.87, 11.75]	1.1 × 10−19	0.061	0.009
HIS	7.16 [3.93, 13.04]	6.2 × 10−11	0.131	0.022

In European (EUR), admixed African (AFR), and Hispanic/Latino (HIS) cohorts, rs11659764 had the most significant association with Fuchs endothelial corneal dystrophy (FECD). The minor allele was associated with an increased odds ratio of FECD risk consistently across ancestry groups, despite differences in effect allele frequency (EAF). CI, confidence interval.