Table 3.

Summary of novel candidate genes

Novel candidate gene	Putative function
SSBP3	Likely binds to polypyrimidine promoter of COL1A2, regulating transcription.
THSD7A	Regulator of endothelial cell migration and adhesion via binding of integrin αvβ3.
LAMB1	Beta-1 subunit of laminin-511; component of basal lamina.
PIDD1	May regulate corneal endothelial cell death via apoptosis.
RORA	Regulator of genes involved in circadian rhythm and oxidative stress.
HS3ST3B1	Regulator of heparan sulfate, which may have a role in corneal homeostasis.
LAMA5	Alpha-5 subunit of laminin-511; component of basal lamina.
COL18A1	Collagen type XVIII subunit; cleaved to form endothelial cell regulator endostatin.

Candidate genes for eight novel loci identified in the multi-ancestry meta-analysis for Fuchs endothelial corneal dystrophy.