FIG. 4.
Host DNA sequence at the integration sites of virus encoding a mutant HIV-1 IN. DNA sequence of the host cell genome at the integration site for each indicated clone is presented. Boxed sequence indicates host DNA deleted during the integration event, and underlined sequence to each side of the box is the host DNA immediately flanking the integrated viral DNA for each clone, matching the flanking DNA in Fig. 3. The deletion at the integration site of each of these clones, ranging from 6 to 11 bp in length, contrasts with the 5-bp direct repeat of host DNA that flanks proviruses generated with wild-type IN (Fig. 3). DNA immediately flanking the D116I-9 integrated provirus, 5 bp on the right and 7 bp on the left, are not of target site DNA origin. These bases are in italics above the target site DNA.