Skip to main content
. Author manuscript; available in PMC: 2024 Apr 7.
Published in final edited form as: Nature. 2023 Nov 8;623(7987):608–615. doi: 10.1038/s41586-023-06704-2

Extended Data Fig. 4 |. Supporting analyses for HHV-6 expression during in vitro CAR T cell culture.

Extended Data Fig. 4 |

(a) Summary of observed (red) and permuted (gray) HHV-6B expression for four donors at day 19 in culture. The dotted line is at 10 UMIs, the threshold for a super-expressor. (b) Heatmap of HHV-6B expression for selected cells across 3 donors with detectable super-expressors. Columns are grouped based on HHV-6B gene programs (immediate early; early; late). (c) UMAP for 3 samples, noting marker genes and HHV-6B UMI expression (log transformed). The WPRE feature indicates the presence of the CAR transgene.