| - Heart failure in functional class III-IV |
| - Pulmonary hypertension |
| - Diabetes |
| - Chronic obstructive pulmonary disease (COPD) and bronchial asthma |
| - Chronic kidney disease, especially patients on dialysis |
| - Cardiac transplantation |
| - Cancer patients |
| - Human Immunodeficiency Virus (HIV) |
| - Other comorbidities: depression, chronic liver disease, alcoholism, connective tissue diseases, bone marrow or other organ transplantation. |
| Immunosuppression and biologic drugs |
|---|
| - Pharmacological: chronic use of corticosteroids, use of monoclonal antibodies, etc. |
| - Non-pharmacological: splenectomized patients. |
