Table 1.

Drugs/proteins associated with mechanism of ferroptosis and mTOR in tumors

Drugs/proteins	Cell lines /tissues	Target	Effect	References
CCI-779	BT474	↓mTOR	Inducing ferroptosis	[98]
Semaphorin 5A	Synovial Fibroblasts (SFs)	↓PI3K/AKT/mTOR	Inhibiting ferroptosis	[42]
Melatonin (MT)	Osteoblasts and Bone Marrow Mesenchymal Stem Cells (BMSCs)	↓PI3K/AKT/mTOR	Inhibiting ferroptosis	[109]
Compound 7j	T24	↓Sxc/GPX4/ROS↓PI3K/Akt/mTOR/ULK1	Inducing ferroptosis/autophagy/apoptosis	[43]
Tocopherol	BMSC	PI3K/AKT/mTOR	Inhibiting ferroptosis	[110]
DHA	HL60/ THP-1	↑AMPK/mTOR/p70S6k	Promoting autophagy/ferroptosis	[48]
IMCA	DLD-1/HCT-116	↓SLC7A11↑AMPK/mTOR/p70S6k	Inducing ferroptosis	[56]
Bisphenol A (BPA)	TCMK-1	↑AMPK/mTOR/ULK1	Promoting autophagy/ferroptosis	[53]
CuSO4	GC-1 spg cells	↑AMPK/mTOR/ULK1	Promoting autophagy/ferroptosis	[51]
Sirtuin 3 (SIRT3)	HTR8	↑AMPK/mTOR↓GPX4	Promoting autophagy/ferroptosis	[59]
AF	U251/U373 glioma; Endometrial Carcinoma Cells	↑AMPK/mTOR	Promoting autophagy/ferroptosis	[60, 61]
Zero-Valent-Iron Nanoparticle (ZVI-NP)	MRC-5 and IMR-90	↑AMPK/mTOR	Inducing ferroptosis	[63]
GNA	B16F10	↓SLC7A11↑AMPK/mTOR	Promoting autophagy/ferroptosis	[111]
Everolimus	HEK-293	↓mTOR/4EBP1	Inducing ferroptosis	[100]
Bupivacaine	T24/5637	↓PI3K/Akt	Inducing apoptosis/ferroptosis	[92]
GALNT14	SKOV3/OVCAR-3	↓EGFR/mTOR	Inducing apoptosis/ferroptosis	[72]
Lapatinib/PAB@Ferritin	MDA-MB-231	↓YAP/mTOR	Promoting autophagy/ferroptosis	[73]
Carboxyl-modified Polystyrene nanoparticles (CPS)	RAW264.7	↓mTORC1	Inhibiting ferroptosis	[75]
Aspirin	DLD-1/HCT 116	↓PI3K/AKT/mTOR/SREBP/SCD1	Inducing ferroptosis	[84]
RSL3	PANC/MIAPaCa	↓mTOR	Promoting autophagy/ferroptosis	[66]
Levobupivacaine	MCF-7 and MDA-MB231	↓PI3K/AKT/mTOR/Bax	Inducing ferroptosis	[94]
Small-Molecule Inhibitor V9302	Triple-negative Breast Cancer; Breast Cancer Stem-Like Cell	↓mTOR	Inducing ferroptosis	[97]