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Strategies for managing GSDMD-related disorders. The activation targeting steps of GSDMD and the functioning mechanisms of existing GSDMD inhibitors are illustrated. Three potential approaches to suppress GSDMD activation are suggested: (i) preventing mutual recruitment of GSDMD and inflammatory caspases; (ii) degrading GSDMD through post-translational modifications; (iii) eliminating GSDMD pores from cell membranes to promote membrane repair. Further details can be found in the text
