Table 1.

Mendelian randomization analysis with forward causality.

Cathepsin	outcome	Inverse variance weighted		MR-Egger		Weighted median
		OR (95%CI)	p_value	OR (95%CI)	p_value	OR (95%CI)	p_value
Cathepsin B	BTC	1.693(1.070-2.681)	0.025	1.893(0.651-5.505)	0.260	1.555(0.816-2.962)	0.180
Cathepsin G	HCC	1.369(1.033-1.814)	0.029	1.309(0.639-2.681)	0.479	1.559(1.049-2.318)	0.028
Cathepsin H	PCa	0.896(0.812-0.988)	0.027	0.948(0.837-1.075)	0.439	0.918(0.832-1.013)	0.089
Cathepsin L2	CRC	0.814(0.674-0.985)	0.034	0.785(0.464-1.325)	0.399	0.810(0.630-1.042)	0.101