FIG. 5.

The combined-treatment regimen inhibits but does not ablate T-cell responses to the vector. Shown are results from one experiment, expression data from which are included in those shown in Fig. 2. Spleens were obtained from mice at the indicated times after intratracheal administration of Ad.RSV-βgal. The results of IFN-γ production (in picograms per milliliter) by cells stimulated with Ad.RSV-βgal are shown. Cells from each group produced similar amounts of IFN-γ in response to stimulation with an anti-CD3 monoclonal antibody used as a positive control. Data are the mean ± SD production of IFN-γ by cells from two or three mice per time point.