Table 1.
Overview of traditional Chinese medicine targeting the PI3K/AKT pathway to alleviate liver fibrosis.
| Compounds | In vitro activity | In vivo activity | Activity in human | References |
|---|---|---|---|---|
| Xiaoyaosan (XYS) | Not assessed | Yes - rats | Not assessed | (74) |
| Sini San (SNS) | Yes - HepGz cells | Yes - mice | Not assessed | (75) |
| Ginsenoside Rh2 (GRHs) | Yes - HSC-TG | Yes - mice | Not assessed | (30) |
| Corn oligopeptides (COPs) | Not assessed | Yes - mice | Not assessed | (76) |
| Dahuang Zhechong Pills (DHZCP) | Not assessed | Yes - rats | Not assessed | (77) |
| Bilberry fruits extract (BEs) | Yes - mouse hepatic AML-12cells | Yes - mice | Not assessed | (78) |
| Propolis | Not assessed | Yes - male BalB/C mice | Not ASSESSED | (79) |
| Corydalis saxicola Bunting Total Alkaloids (CSBTA) | Yes - HepG2 | Yes - mice | Not assessed | (80) |
| Ginsenoside Rk3 | Not assessed | Yes - C57BL/6 mice | Not assessed | (14) |
| Arctigenin (ATG) | Yes - HSCs | Yes | Not assessed | (7) |
| Astragaloside IV (AS-IV) | Not assessed | Yes - rats | Not assessed | (81) |
| Dihydroartemisinin (DHA) | Yes - HSCs | Yes - rats | Not assessed | (82) |
| Germacrone (GM) | Yes - HSC- LX-2 | Yes - rats | Not assessed | (69) |
| Gypenosides | Yes - HSCs | Yes - rats | Not assessed | (83) |
| Songyou Yin (SYY) | Yes - HSCs | Yes - nude mice | Not assessed | (84) |
| Lycium barbarum polysaccharides (LBPs) | Not assessed | Yes - female rats | Not assessed | (85) |
| Puerarin | Not assessed | Yes - C57BL/6 J mice | Not assessed | (86) |
| Total alkaloids of Corydalis saxicola Bunting (TACS) | Not assessed | Yes - rats | Not assessed | (87) |
| Semen Brassicae extract | Not assessed | Yes - Male Sprague–Dawley rats | Not assessed | (34) |
| Sennoside A (SA) | Yes - HSC-T6 cells | Yes - mouse | Not assessed | (88) |
| Yu Jin Pulvis (YJP) | Not assessed | Yes - mouse | Not assessed | (89) |
| Yu Gan Long (YGL) | Not assessed | Yes - rat | Not assessed | (9) |
| Didymin | Yes - HSCs | Yes - rat | Not assessed | (90) |
| Silibinin | Yes - LX-2 | Not assessed | Not assessed | (91) |
| Caffeic acid phenethyl ester (CAPE) | Yes - HSC-T6 | Yes - male Sprague–Dawley rats | Not assessed | (92) |
| Ginsenoside Rg2 | Yes - HSC-T6 | Yes - rat | Not assessed | (38) |
| Glycyrrhizin (GL) | Yes - splenic CD4(+)T cells | Yes - concanavalin A (ConA)-induced mouse | Not assessed | (93) |
| Thymoquinone | Yes - T-HSC/Cl-6 | Yes - mice | Not assessed | (94) |
| Berberine | Yes - HSC | Yes - classical mouse | Not assessed | (95) |
| Tanshinol | Not assessed | Yes - male Sprague–Dawley (SD) rats. | Not assessed | (96) |
| Curcumin | Yes - HSC | Yes - rats | Not assessed | (97) |