Table 1. Baseline characteristics of patients in the low and high LDL-C groups.
|
Overall (n = 410) |
Low LDL-C group (n = 172) |
High LDL-C group (n = 238) |
p-value | |
|---|---|---|---|---|
| Age, years | 65±13 | 68±12 | 63±12 | ＜0.0001 |
| Male sex, n (%) | 337 (82.2) | 147 (85.5) | 190 (79.8) | 0.14 |
| Body mass index, kg/m² | 24.0±3.5 | 23.9±3.7 | 24.0±3.4 | 0.56 |
| Hypertension, n (%) | 247 (60.2) | 112 (65.1) | 135 (56.7) | 0.09 |
| Diabetes mellitus, n (%) | 122 (29.8) | 66 (38.4) | 56 (23.5) | 0.001 |
| Current smoker, n (%) | 201 (49.1) | 82 (48.0) | 119 (50.0) | 0.68 |
| History of MI, n (%) | 21 (5.1) | 6 (3.5) | 15 (6.3) | 0.20 |
| With cancer, n (%) | 17 (4.2) | 8 (4.7) | 9 (3.8) | 0.66 |
| eGFR on admission, mg/dL | 68.0 [55.6-80.4] | 66.3 [51.6-75.1] | 70.6 [57.4-83.5] | 0.004 |
| HDL-C on admission, mg/dL | 44 [38-52] | 42 [37-51] | 45 [39-53] | 0.02 |
| LDL-C on admission, mg/dL | 130 [108-156] | 103 [92-113] | 152 [137-171] | ＜0.0001 |
| TG on admission, mg/dL | 121 [81-186] | 119 [76-192] | 122 [85-183] | 0.96 |
| BNP on admission, pg/mL | 49 [21-120] | 57 [25-151] | 44 [17-108] | 0.03 |
| hs-CRP ≥ 0.2 mg/dL on admission, n (%) | 191 (46.7) | 79 (45.9) | 112 (47.3) | 0.79 |
| hs-CRP ≥ 0.2 mg/dL in the chronic phase, n (%) (n = 399) | 90 (22.6) | 43 (25.4) | 47 (20.4) | 0.24 |
| GNRI ＜92, n (%) | 33 (8.1) | 17 (9.9) | 16 (6.8) | 0.24 |
| LVEF on admission, % | 50±11 | 50±12 | 50±11 | 0.84 |
| STEMI, n (%) | 301 (73.4) | 117 (68.0) | 184 (77.3) | 0.04 |
| Multivessel disease, n (%) | 182 (44.4) | 82 (47.7) | 100 (42.0) | 0.26 |
| Medication at discharge | ||||
| Aspirin, n (%) | 406 (99.0) | 170 (98.8) | 236 (99.0) | 0.74 |
| Beta blocker, n (%) | 252 (61.6) | 102 (59.7) | 150 (63.0) | 0.49 |
| ACE-I or ARB, n (%) | 333 (81.2) | 137 (79.7) | 196 (82.4) | 0.49 |
| Strong statin, n (%) | 382 (93.2) | 146 (84.9) | 236 (99.2) | ＜0.0001 |
| Gait speed, m/s (n = 344) | 0.85±0.23 | 0.84±0.22 | 0.86±0.23 | 0.45 |
| Ln RHI | 0.59±0.26 | 0.57±0.25 | 0.61±0.26 | 0.12 |
Variables are expressed as numbers (percentages), mean±SD, or median [25th-75th percentile].
ACE-I, angiotensin-converting enzyme inhibitor; ARB, angiotensin II receptor blocker; BNP, B-type natriuretic peptide; eGFR, estimated glomerular filtration rate; GNRI, geriatric nutritional risk index; HDL-C, high-density lipoprotein cholesterol; hs-CRP, high-sensitivity C-reactive protein; LDL-C, low-density lipoprotein cholesterol; Ln RHI, logarithmic value of reactive hyperemia index; LVEF, left ventricular ejection fraction; MI, myocardial infarction; SD, standard deviation; STEMI, ST-segment elevation myocardial infarction; TG, triglycerides.