Table 1.
Inhibitory effect of 5a-d and 8a-9b on RPMI-8226 and U266 cell lines.
| Compounds | R1 | R2 | IC50(μM)a RPMI-8226 | IC50 (μM)a U266 |
|---|---|---|---|---|
| 5a |  |
 |
2.22 ± 0.21 | 2.45 ± 0.08 |
| 5b | |
 |
0.85 ± 0.14 | 0.97 ± 0.11 |
| 5c | |
 |
4.35 ± 0.48 | 4.15 ± 0.24 |
| 5d | |
 |
0.96 ± 0.15 | 0.89 ± 0.09 |
| 6a | |
H | 5.14 ± 0.24 | 4.96 ± 0.58 |
| 6d | |
H | 4.93 ± 0.34 | 5.24 ± 0.33 |
| 8a | |
 |
2.18 ± 0.41 | 2.44 ± 0.89 |
| 8b | |
 |
4.98 ± 0.56 | 4.26 ± 1.56 |
| 8c | |
 |
4.95 ± 0.12 | 4.70 ± 1.11 |
| 8d | |
 |
4.56 ± 0.11 | 4.23 ± 1.35 |
| 8e | |
 |
2.85 ± 0.44 | 2.65 ± 0.88 |
| 8f | |
 |
1.32 ± 0.55 | 1.45 ± 0.12 |
| 8g | |
 |
0.98 ± 0.10 | 1.01 ± 0.09 |
| 8h | |
 |
2.92 ± 0.48 | 2.66 ± 0.17 |
| 8i | |
 |
2.22 ± 0.17 | 1.98 ± 0.28 |
| 8j | |
 |
2.56 ± 0.29 | 2.77 ± 0.46 |
| 8k | |
 |
1.99 ± 0.07 | 1.76 ± 0.77 |
| 8l | |
 |
5.13 ± 0.44 | 5.44 ± 0.59 |
| 8m | |
 |
2.40 ± 0.59 | 2.67 ± 0.88 |
| 8n | |
 |
2.03 ± 0.27 | 1.88 ± 0.44 |
| 8o | |
 |
1.99 ± 0.39 | 2.66 ± 0.98 |
| 8p | |
 |
1.04 ± 0.11 | 1.44 ± 0.44 |
| 8q | |
 |
1.18 ± 0.79 | 1.05 ± 0.89 |
| 8r | |
 |
1.11 ± 0.26 | 1.55 ± 0.16 |
| 8s | |
|
1.87 ± 0.36 | 1.66 ± 0.05 |
| 8t | |
 |
2.05 ± 0.58 | 1.99 ± 0.49 |
| 8u | |
|
2.45 ± 0.84 | 2.63 ± 0.33 |
| 8v | |
|
2.32 ± 0.54 | 2.20 ± 0.29 |
| 8w | |
|
2.21 ± 0.28 | 2.46 ± 0.37 |
| 8x | |
|
1.99 ± 0.07 | 2.23 ± 0.24 |
| 8y | |
 |
1.27 ± 0.53 | 1.34 ± 0.57 |
| 8z | |
|
1.02 ± 0.07 | 1.24 ± 0.48 |
| 9a | |
 |
1.88 ± 0.12 | 1.59 ± 0.19 |
| 9b | |
|
1.76 ± 0.19 | 1.98 ± 0.42 |
a
IC50, the mean ± SD of 3 independent experiments.