Table 2.
Modulation of endogenous metabolites quantified in (A) NMR spectra and (B) endogenous lipids quantified by SFC-HRMS profiling of plasma samples and selected by multiblock sPLS-DA. Fold change (FC) corresponds to the ratio of the mean NMR areas or MS intensities (Decline/No decline). SM = Sphingomyelin; TG = Triglycerides
| A | ||||
|---|---|---|---|---|
| Metabolite | Chemical shift (ppm) | FC | Superpathway | Subpathway |
| 3-Hydroxybutyrate | 1.20 ; 2.32 ; 2.39 and 2.42 | 0.72 | Lipids | Ketone bodies |
| Citrate | 2.51 | 0.81 | Energy | TCA cycle |
| Succinate | 2.41 | 0.79 | Energy | Succinate pathway |
| Acetone | 2.24 | 0.85 | Ketone bodies | |
| Methionine | 2.66 | 0.92 | Amino acid | Methionin pathway |
| Glucose | 3.75 | 1.09 | Carbohydrate | Glycolysis, gluconeogenesis, metabolism |
| Serine | 4.01 | 1.11 | Amino acid | Methionin pathway |
| B | ||||
|---|---|---|---|---|
| Lipids | FC | Superpathway | Subpathway | |
| SM (d18:1/C26:0) | 1.535 | Lipids | Sphingolipid metabolism | |
| TG (C48:3) | 1.536 | Lipids | ||