FIG. 2:

Contribution of CRAMP to colon microbiota balance. CRAMP-deficient mice show severe dysbiosis in the colon. This is verified by cohousing and single housing of WT mice (A) and CRAMP^−/− mice (B). Single-housed CRAMP^−/− mice show a significantly altered phenotype, including shortened colon crypts, thinner mucus layer, and dysbiosis with a different microbiota composition in the feces from that of single housed WT mice. WT mice cohoused with CRAMP^−/− mice adopted a similar phenotype and microbiota composition from CRAMP^−/− mice (C).