Table 1.
Echocardiography.
| Before Doxy | 10 weeks of Doxy | 18 weeks of Doxy | ||||
|---|---|---|---|---|---|---|
| WT | TG | WT | TG | WT | TG | |
| HR, beats/min | 449 [11] | 444 [11] | 447 [15] | 428 [9] | 432 [12] | 398 [11] |
| IVS,d (mm) | 0.73 (0.05) | 0.76 (0.04) | 0.74 (0.04) | 0.75 (0.02) | 0.75 (0.03) | 0.79 (0.03) |
| IVS,s (mm) | 1.00 (0.03) | 1.05 (0.05) | 1.06 (0.03) | 1.11 (0.04) | 1.10 (0.04) | 1.23 (0.02)***, &&& |
| LVID,d (mm) | 4.23 (0.05) | 4.11 (0.16) | 4.21 (0.12) | 4.04 (0.11) | 4.12 (0.07) | 3.91 (0.14) |
| LVID,s (mm) | 3.16 (0.02) | 3.11 (0.18) | 3.2 (0.09) | 2.71 (0.13) | 3.08 (0.07) | 2.58 (0.08)***, &&& |
| LVPW,d (mm) | 0.66 (0.03) | 0.70 (0.03) | 0.75 (0.02) | 0.77 (0.03) | 0.79 (0.03) | 0.77 (0.03) |
| LVPW,s (mm) | 1.06 (0.04) | 1.00 (0.04) | 1.04 (1.2 | 1.05 (0.03 | 1.06 (0.03) | 1.11 (0.04) |
| EF (%) | 50 (1.2) | 49 (2.8) | 48.2 (1.2) | 62.1 (2.1)***, &&& | 50.2 (1.0) | 63.3 (2.0)***, &&& |
| FS (%) | 25.2 (0.8) | 24.6 (1.6) | 24.1 (0.8) | 33.1 (1.4)***, &&& | 25.2 (0.6) | 33.9 (1.6)***, &&& |
M mode cardiac echocardiography. HR: heart rate. Left ventricular inner diameter at end-diastole (LVID,d) and end-systole (LVID,s), left-ventricular posterior wall thickness at end-diastole (LVPW,d) and end-systole (LVPW,s), interseptal wall thickness at end-diastole (IVS,d) and end-systole (IVS,s), ejection fraction (EF) and fractional shortening (FS) were measured serially at indicated time points during doxy feeding. Values are mean ± SEM; n = 5/genotype; statistics: two-way ANOVA; P < 0.001 for time × genotype; P-values shown are from post hoc Tukey test: ***P < 0.001 for WT versus TG at a given time point, &&&P < 0.001 for TG time 0 versus TG 10 weeks and versus TG 18 weeks).