FIGURE 7.

Preliminary clinical connections of mouse findings based on NCI human MM RNA-seq and germline mutation data (16). A, Comparison of CCL2 mRNA expression levels based on BAP1 germline mutation status in 100 MM samples from the NCI cohort. Statistical analysis was performed using the Student t test. B, Immunoblot analyses of CCL2 in human MM cell lines with or without loss of BAP1 expression. GAPDH was used as a loading control. C, Scatter plots depicting the relationship between CD163 and CCR2, ENTPD1 (CD39), IL10, IL10RA, MRC1 (CD206), and STAT3 mRNA expression levels. Statistical analysis for this correlation study was conducted using Spearman rank-order correlations (r) and P values.