Table 1.

History of Preclinical Studies on Cyclophosphamide-Induced Tolerance

Cy prolongs allogeneic skin graft survival in mice	Reference 8
Cy most effective agent in preventing Ab production in mice	Reference 5
Confirmation that Cy can prevent Ab production in mice	Reference 6
Cy prolongs allogeneic skin graft survival in rats	Reference 7
PTCy limits GVHD in mice	Reference 13
PTCy limits GVHD in mice, but is most effective at high doses	Reference 18
Confirmation that PTCy can limit GVHD in mice	Reference 20
Both allogeneic antigens and stem cells are needed for Cy-induced skin allograft tolerance in mice	Reference 10
Cy prolongs survival of allogeneic heart grafts in mice	Reference 11
CsA interferes with allogeneic skin graft survival in mice	Reference 12
PTCy allows haplo BMT after nonmyeloablative conditioning in mice	Reference 25

Cy – cyclophosphamide, PTCy – post-transplant cyclophosphamide, Ab – antibody, GVHD – graft-vs-host disease, CsA – cyclosporine, haplo – haploidentical, BMT – blood or marrow transplantation