Table 3.

The binding energy of the compounds and core targets (kcal/mol).

Target	Target (PDB ID)	Target structure	Compound	Affinity (kcal/mol)
ALB	1N5U		Quercetin	−8.1
			Kaempferol	−7.0
			Licochalcone A	−8.0
			Naringenin	−8.5
			6,7-Dimethoxy-2-(2-phenylethyl) chromone	−9.6
AKT1	1H10		Quercetin	−6.1
			Kaempferol	−6.0
			Licochalcone A	−6.3
			Naringenin	−6.1
			6,7-Dimethoxy-2-(2-phenylethyl) chromone	−6.2
INS	1HTV		Quercetin	−7.9
			Kaempferol	−5.8
			Licochalcone A	−6.6
			Naringenin	−7.8
			6,7-Dimethoxy-2-(2-phenylethyl) chromone	−8.6
TNF	1TNF		Quercetin	−6.3
			Kaempferol	−6.4
			Licochalcone A	−5.5
			Naringenin	−6.8
			6,7-Dimethoxy-2-(2-phenylethyl) chromone	−5.4
IL6	7NXZ		Quercetin	−6.4
			Kaempferol	−6.8
			Licochalcone A	−5.2
			Naringenin	−5.3
			6,7-Dimethoxy-2-(2-phenylethyl) chromone	−5.4