Table 1.

Major milestones in ferroptosis research in last two deacdes.

Year	Milestones		References
	Molecules	Roles
2003	Erastin	Mutant RAS selective compound	[22]
2007	Vitamin-E	Antioxidant	[22]
	VDAC2/3	Mitochondrial porins	[22]
	Mutated RAS	Oncogene	[22]
2008	TFRC	Iron transporter	[22]
	RSL3 RSL5	Mutant RAS selective compounds	[22]
	DFO	Iron chelator	[22]
2010	ML162 ML210	Mutant RAS selective compounds	[23–25]
2012	SLC7A11	Cystine/glutamate transporter. Coined the term ferroptosis	[22]
	Ferrostatin-1	Ferroptosis inhibitor	[22]
	Sulfasalazine	SLC7A11 inhibitor	[22]
2014	GPX4	Phospholipidhydroperoxidase	[22]
	Sorafenib	SLC7A11 inhibitor	[22]
	Liporoxststin-1	Ferroptosis inhibitor	[26]
	Zileuton	ALOX inhibitor	[27]
2015	SLC38A1	Glutamine transporter	[28–30]
	HSPB1	Heat shock protein	[31]
	TP53 (mutated tumor suppressor gene)	Transcription factor	[32]
	Artesunate	Antimalarial agent	[33]
	IKE	SLC7A11 inhibitor	[22]
2016	ACSL4	Lipid biosynthesis	[34]
	FIN56	GPX4 and coenzyme Q10 (CoQ10) inhibitor	[22]
	NEF2L2	Transcription factor	[35]
	NCOA4	Ferritinophagy	[28–30]
	ALOXs	Lipoxygenases	[22]
	FINO2	Inactivation of GPX4 & oxidation of Fe	[36]
	Statins	HMG-CoA reductase	[22]
2017	BH3-interacting domain death agonist (BID)	BCL2 family	[37]
	ZEB1	EMT-activator	[38]
	ITGA6-ITGB4	Cell adhesion	[39]
	Hemoglobin Hemin	Iron-containing protein	[40]
	Rosiglitazone	ACSL4 inhibitor	[41]
2018	BAP1	Epigenetic regulation	[42]
	NECTIN4	Cell clustering	[43]
	CTSB	Lysosomal cell death	[31]
	Withaferin A	Increase iron	[44]
	LOX-Block-1	ALOX inhibitor	[45]
2019	YAP1 NF2 WWTR1	Cell contact	[46]
	Apoptosis-inducing factor mitochondria-associated 2 (AIFM2)	CoQ10 production	[47]
	Cyst(e)inase	Cysteine depletion	[48]
	Ferroptocide	Thioredoxin inhibitor	[49]
	iFSP	AIFM2 inhibitor	[50]
2020	PEX10 PEX3	Peroxisome	[51]
	GCH1	BH4 production	[52]
	CHMP5 CHMP6	ESCRT-III membrane repair	[31]
	POR (p450 reductase)	Phospholipid peroxidation	[53]
	Zalcitabine	Antiretroviral agent	[31]
	Quercetin	Antioxidant agent	[54]
2023	Piezo1 & TRP channels	Cooperatively promote ferroptosis by facilitating cation flux	[55]