TABLE 3.

Fifteen Highlights From 15 Years of Mechanistic Human Studies in the Intersection of Coagulation and Inflammation in Injury

Xiao W, Mindrinos MN, Seok J, Cuschieri J, Cuenca AG, Gao H, et al. A genomic storm in critically injured humans. J Exp Med. 2011;208:2581–90.

Cohen MJ, Call M, Nelson M, Calfee CS, Esmon CT, Brohi K, et al. Critical role of activated protein C in early coagulopathy and later organ failure, infection and death in trauma patients. Ann Surg. 2012;255:379–85.

Johansson PI, Sorensen AM, Perner A, Welling KL, Wanscher M, Larsen CF, et al. High sCD40L levels early after trauma are associated with enhanced shock, sympathoadrenal activation, tissue and endothelial damage, coagulopathy and mortality. J Thromb Haemost. 2012;10:207–16.

Burk AM, Martin M, Flierl MA, Rittirsch D, Helm M, Lampl L, et al. Early complementopathy after multiple injuries in humans. Shock. 2012;37:348–54.

Moore HB, Moore EE, Chapman MP, McVaney K, Bryskiewicz G, Blechar R, et al. Plasma-first resuscitation to treat haemorrhagic shock during emergency ground transportation in an urban area: a randomized trial. Lancet. 2018;392:283–91.

Vulliamy P, Gillespie S, Armstrong PC, Allan HE, Warner TD, Brohi K. Histone H4 induces platelet ballooning and microparticle release during trauma hemorrhage. Proc Natl Acad Sci USA. 2019 Aug 27;116(35):17444–17449.

Barrett CD, Vigneshwar N, Moore HB, Ghasabyan A, Chandler J, Moore EE, et al. Tranexamic acid is associated with reduced complement activation in trauma patients with hemorrhagic shock and hyperfibrinolysis on thromboelastography. Blood Coagul Fibrinolysis. 2020;31:578–82.

Dyer MR, Plautz WE, Ragni MV, Alexander W, Haldeman S, Sperry JL, et al. Traumatic injury results in prolonged circulation of ultralarge von Willebrand factor and a reduction in ADAMTS13 activity. Transfusion. 2020;60:1308–18.

Goswami J, MacArthur T, Bailey K, Spears G, Kozar RA, Auton M, et al. Neutrophil extracellular trap formation and Syndecan-1 shedding are increased after trauma. Shock. 2021;56:433–9.

Janicova A, Becker N, Xu B, Simic M, Noack L, Wagner N, et al. Severe traumatic injury induces phenotypic and functional changes of neutrophils and monocytes. J Clin Med. 2021;10.

Schaid TR, Jr., Hansen KC, Sauaia A, Moore EE, DeBot M, Cralley AL, et al. Postinjury complement C4 activation is associated with adverse outcomes and is potentially influenced by plasma resuscitation. J Trauma Acute Care Surg. 2022;93:588–96.

Knudson MM, Moore EE, Kornblith LZ, Shui AM, Brakenridge S, Bruns BR, et al. Challenging traditional paradigms in posttraumatic pulmonary thromboembolism. JAMA Surg. 2022 Feb 1;157(2):e216356.

Schaid TR, Jr., LaCroix I, Hansen KC, D’Alessandro A, Moore EE, Sauaia A, et al. A proteomic analysis of NETosis in trauma: emergence of serpinB1 as a key player. J Trauma Acute Care Surg. 2023;94:361–70.

Shimono K, Ito T, Kamikokuryo C, Niiyama S, Yamada S, Onishi H, et al. Damage-associated molecular patterns and fibrinolysis perturbation are associated with lethal outcomes in traumatic injury. Thromb J. 2023;21:91.

Bonaroti J, Billiar I, Moheimani H, Wu J, Namas R, Li S, et al. Plasma proteomics reveals early, broad release of chemokine, cytokine, TNF, and interferon mediators following trauma with delayed increases in a subset of chemokines and cytokines in patients that remain critically ill. Front Immunol. 2022 Nov 30;13:1038086.