FIG. 4.

Summary of the sites within the HCV (A) and CSFV (B) IRESs that are protected from modification by CMCT and DMS and from cleavage by the single-strand-specific RNase ONE and the double-strand-specific RNase V₁. These chemical and enzymatic probes are indicated by symbols at the upper left. The results are displayed on secondary-structure models of the upper half of domain III that are based on previous proposals (5) (A) and on the results shown in Fig. 1 (B). Domains and subdomains are described according to the nomenclature in reference 11.