Fig. 4.

Gene Ontology (GO) enrichment analysis after proteins quantification on the concentric circles pattern. Top 9 significantly enriched GO (−log10 (p-value) >1.3) terms of the target genes in the cellular components, molecular function, and biological processes domains, either (a) up- or (b) down- regulated, resulted from DAVID software analysis. The complete list of GO annotation for the significantly differentially expressed associated genes is reported in supplementary information Fig. S5.